Özet:

Isoniazid (INH) is an anti-tuberculosis drug which is widely used in the treatment and prevention of tuberculosis. Acute INH intoxication leads to resistant seizure to standard anticonvulsants, high anion-clear metabolic acidosis resistant to sodium bicarbonate treatment and coma. Parenteral pyridoxine administration in the same amount with the INH dose is the most effective treatment. We present a case of a 24-year-old woman who diagnosed with left shoulder dislocation and fracture secondarily to generalized tonic clonic seizure due to acute INH intoxication. The patient who was referred to ED due to syncope had a seizure upon examination, loss of consciousness and metabolic acidosis was also detected. It was learned that the patient who restored to consciousness after treatment, had used INH for skin involvement of tuberculosis and also recieved INH again mistakenly for nighttime dose. The patient was monitored 24 hours and discharged with a cure upon there was no seizure in monitoring, non-development of any other additional symptoms and because of improvements in metabolic parameters. In conclusion, it should also be considered to have intoxication of INH in patients who referred with unstoppable seizures, metabolic acidosis and coma, thus parenteral pyridoxine must definitely be provided in emergency departments.

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