Özet:

Purpose: Breast cancer is a type of cancer that causes death with a fist that is common among women. Many tumor suppressor genes, oncogen and DNA repair genes play a role in breast cancer formation. The tumor suppressor genes are known to cause BRCA-1-2 breast cancer. This study examined the frequency of polymorphism mutations in the BRCA-1-2 genes that were performed in other regions of our country. In our study, a group of young people (44 years under age) diagnosed breast cancer at the Dicle University Oncology Science Division studied the tumor tissue of 96 patients. We aimed at determining the polymorphic mutations of the genes BRCA-1 (rs16942, rs1799966) and BRCA-2 (rs144848, rs1799944) using the "LightCycler" PCR device with the Hybridization Prob Method from the PCR specific determination group. Results: 14 (%14,5) homozigot (GG), 55 (%57.3) heterozigot (AG) in rs16942 of study patients; 18 (%18.7) homozigot (GG) in rs1799966; 46 (%47.9) heterozigot (AG); 9 (%9.37) homozigot (TT), 25 (%26.04) heterozigot (GT) in rs1799944; 2 (%2.08) homozigot (GG) in rs1799944; 3 (%3.12) heterozigot (AG) in rs144848; 2 (%9.37) homozigot (TT) in rs144848; 2 (%26.04) heterozigot (GT) in rs1799944; 3 (%3.12) heterozigot (AG) We found that these mutations are not related to disease age group, stage, grade, ER positive and HER-2 positive. In age and age, the rate of mutations under 35 years old, in stage 2 and stage 3, in grade 2 and grade 3 the rate of mutations increased numerically and the value of p had no clinical significance. The result: BRCA-1-2 polymorphism mutations are significant in our region and it is important to scan patients and families. We found that these polymorphism mutations in BRCA-1/BRCA-2 have no relation to age, stage, grade, state of ER, state of HER.