Abstract:

Purpose: Enterobacteriaceae family and especially Klebsiella pneumoniae treatment are infectious factors where treatment options become even more limited, along with difficult and increased resistance. Our study aims to identify the demographic characteristics of patients infected with carbapenem-resistant Enterobacteriaceae KDE and the risk factors for infection. Tools and Methods: From January 2010 to April 2014 we were included in the study as a group of 25 patients diagnosed with the infection in which the KDE was active. The incident group was identified as a total of 71 patient control groups in the same period and in the same clinic. For both groups, the demographic characteristics of the patients and related health care characteristics were assessed.Discussions: in 20% of patients, K. Pneumoniae was isolated at 2 % in Escherichia coli, 2 % in Enterobacter cloaca, 1 % in Enterobacter aerogenes. In the single variable analysis, SAPS II found the history of inflation in the UI and the use of antibiotics in the last 3 months as significant risk factors p≤0,05 . In logistic regression analysis, SAPS II OR 0.95; 95% GA 0.90-0.99, p=0.03; INSTITUTION HISTORY OR 8.5; 95% GA 2.25-32,51, p=0.04 and antibiotic use in the last 3 months OR 0.01; 95% GA 1.3-1,7, p=0.01 were identified as independent variables in terms of being a risk factor for cholistine-resistant microorganism infection. In the treatment of thirteen patients, monotherapy, combined antibiotic therapy was used in the treatment of 10 patients. The group of antibiotics in which KDE isolates are most sensitive was identified as amino glycosides. The result: Infections caused by KDE are a health care problem that should be linked to increased morbidity and mortality and due to limited treatment alternatives with strict control measures. For this purpose, studies involving more patients and risk factors need to be addressed.

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