Özet:

The purpose of the current study is to formulate and develop an emulsion gel (oil-in -water) which removes all obstacles related to its diffusion, stability and irritation of ascorbic acid. Pursued this study with preformulation and determined melting point (190.3±0.577), solubility, preferably soluble in water and 7.4 Phosphate buffer solution. Drug identification studies were performed by UV spectrophotometer and FTIR. The ʎmax of ascorbic was found at 260nm while during FTIR studies, all important peaks were observed, showed the authenticity of the drug. Drug and the excipient were found compatible. Nine formulations of emulsion were formulated by the dispersion method and they were evaluated for particle size diameter (138.71 nm), zeta potential (-37.2mV), optical microscopy, drug content (99.211±0.202) which was found with in limit, of drug was, the globule size discovered by TEM and observed spherical in shape. Among all nine formulations, F5 showed its best results and it was used for further emulsion gel preparation. The Carbopol 934 p polymer was used with varies concentration from 0.5 to 2% for gel preparation and it was added into F5 formulation and noted that, while 1% polymer concentration was used, it has given the best release (99.778±0.073 in 6 hours), stability and viscosity.

Anahtar Kelimeler: