Özet:

Purpose: Epoxycosatrienoic acids (EETs) have a variety of beneficial effects on the cardiovascular system, stimulating arterial vasorelaxation, lowering blood pressure, anti-inflammatory effects. The soluble epoxide hydrolase (CEH) encoded by the EPHX2 gene converts EETs into fewer bioactive diols. CHEH inhibition has been shown to have a positive effect on animal models of many cardiovascular diseases, including abdominal aort anevrism (AAA). The coronary arterial disease of K55R polymorphism in the EPHX2 gene, which has caused an increase in the ceh activity, is associated with the development of ischemic injury. However, it is not known whether the K55R polymorphism is associated with AAA. Therefore, the purpose of this study is to study the relationship between AAA and EPHX2 K55R polymorphism. In this study, 75 healthy and 50 AAA patients analyzed K55R polymorphism. Genotyping of K55R polymorphism was performed with real-time PCR using double-colored hydrolysis probes. There is no significant difference between the patient and the control group in the genotype distribution of K55R polymorphism. Furthermore, it was found that in individuals with heterozigot genotype for K55R polymorphism, the risk of developing AAA was 1.63 times higher than in individuals with wild-type alel, but this result did not reach a statistically meaningful value. The result: As a result, heterozigot individuals 1. Although they have a 63 times higher risk rate for developing AAAs, statistical findings have shown that there is no connection between EPHX2 K55R polymorphism and AAAs in a Turkish population. However, additional studies are needed in different populations, including more individuals and/or different sources, to evaluate the relationship between this polymorphism and AAA. Keywords: Epoxycozatrinoic acid; abdominal aort aneurysm; soluble epoxite hydrolase; polymorphism