Abstract:

Aim: Molecular subtypes in invasive breast cancer is a classification system based on tumor biology rather than tumor morphology. The aim of this study is to find out whether the age of 65, which is accepted as the elderly population limit, could be an independet risf factor on the molecular basis in invasive breast cancer. Materials and Methods: 512 patients who underwent mastectomy with a diagnosis of breast cancer between 2012 and 2021 at the Department of General Surgery of Ankara City Hospital were retrospectively analyzed. The patients were divided into two groups as elderly (≥65 years old) and young (<65 yeras old) according to the data of the World Health Organization (WHO). Results: The relationship of the groups with hormone receptors and molecular subtypes was evaluated. We found a statistically significant difference in the distribution of elderly and young patients according to molecular subtypes (p=0.038). Luminal A was seen at a higher rate in patients ≥65 years of age than in patients <65 years of age (OR=0.527, 95% Cl: 0.328-0.846, p=0.008) Conclusion: We found that a demographic factor in invasive breast cancer may have a relationship with tumor biogenetics. The age of 65, which is used to differentiate between young and elderly populations, may be a determining factor in determining the hormone receptor status and molecular subtypes in invasive breast cancer patients.

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