Özet:

Objective: It is known that high Lipoprotien (a) [Lp (a)] levels are associated with an increased risk of coronary artery disease. In our study, we planned to investigate the relationship between serum Lp (a) level and clinical presentation in patients admitted for the first time with the diagnosis of acute coronary syndrome. Materials and Methods: Patients presenting with acute coronary syndrome for the first time were included in our study prospectively. Demographic data of the patients were collected from file records. Measurement of Lp (a) and other lipid parameters was made from venous blood taken after at least eight hours of fasting after hospitalization. Results: A total of 237 patients, including 105 patients with ST-segment elevation myocardial infarction (STEMI) and 132 patients with non-ST-segment elevation myocardial infarction (NSTEMI), were included in the study. There was no significant difference between the groups in terms of age and gender. Although serum Lp (a) levels were found to be higher in STEMI patients, there was no significant difference between the two groups [10.2 (19.7) mg/dl vs. 8.5 (12.7) mg/dl, p: 0.393]. Patients with Lp(a) ≥ 30 mg/dl and LDL ≥ 100 mg/dl are 4.95 times more likely to present to a STEMI clinic than those with LDL < 100 mg/dl (odds ratio: 4.95, 95% confidence interval: 1.31- 16.5, p:0.027). On the other hand, we found that patients with LDL ≥ 100 mg/dl and Lp(a) ≥ 30 mg/dl presented with STEMI clinics 2.45 times more than those with Lp(a) < 30 mg/dl (odds ratio: 2.45, 95% confidence interval: 1.04-5.6, p:0.039). Conclusion: We found that the clinical presentations of acute coronary syndrome in patients with Lp (a) ≥ 30 mg/dl and LDL ≥ 100 mg/dl were in favor of STEMI. Earlier and more effective lifestyle changes seem to be needed in this patient group.