Özet:

The aim of the study: to improve quality of early diagnosis, to determine new link of pathogenesis and develop prognostic criteria of peripheral neuropathy course in patients with rheumatoid arthritis. Study material and methods: overall, 131 patients aged from 17 to 79 years (46+/-1 years on average) with rheumatoid arthritis were enrolled into the study, of these 25±1 % male and 75±1 % female. Disease duration was 9 years. NJR (articular count), IR (index Richi) and IL (index Lansburi) were evaluated. Index DAD (overall disease activity) in points and criteria DAS28 (index of arthritis activity for 28 joints) were determined to evaluate overall activity of inflammatory joint diseases. Radiological and sonographic examination of peripheral, sacroiliac joints and vertebral column were performed. Results and discussion: peripheral neuropathy was diagnosed in 17 (13.0±1 %) of patients with rheumatoid arthritis, which were enrolled into the main group, other 114 patients remained in control group. Peripheral neuropathy was observed in 13±0.1 % of patients with rheumatoid arthritis as polyneuropathy and mononeuropathy in 5:1 ratio with motorial, sensor, vegetative and mixed disorders in ratio 1:2:3:3, in ½ of cases patients had tunnel syndrome. This is linked to the patient gender (more often with male), tendovaginitis presence, digital arteritis, ophthalmopathy, myositis and spondylopathy. Osteochondrosis and spondylarthrosis have been observed in ½ of patients with rheumatoid arthritis, moreover clinical manifestation of disease was revealed in 35.1±0.1 % of cases which linked to patients age, damage of wrist, elbow, hip and sacroiliac joints, presence of general osteoporosis and tendovaginitis, sensor and motorial disorders. Conclusions: peripheral neuropathy more often has been observed in male, patients with tendovaginitis, digital arteritis, ophthalmopathy, myositis and spondylopathy. Severity of course was influenced by wrist joint arthritis and presence of joint calcification. Level of IL and DAS28 might be prognostic criteria of peripheral neuropathy course in patients with rheumatoid arthritis Author Biography Ganna Perepada, Donetsk National Medical University Kirova str., 27, Liman, Donetsk region, Ukraine, 84404 Postgraduate student Department of Neurology and Neurosurgery

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