Abstract:

Objectives: In the treatment of chronic hepatitis C (CHC), very high rates of sustained virological response (SVR) have been obtained with direct-acting antivirals. In this study, we aimed to evaluate the efficacy and safety of therapies containing ledipasvir + sofosbuvir (Led + Sof), Sof, paritaprevir/ritonavir/ombitasvir + dasabuvir (PrOD) and PrO. Materials and Methods: Three hundred patients with CHC, who received Led + Sof, Sof, PrOD or PrO treatment were included in the study. Results: One hundred two (34%) of the patients were treatmentnaive patients and 198 (66%) had undergone treatment. Cirrhosis was present in 70 (23.3%) of the patients. Thirty-five (11.7%) of the patients were with genotype 1a, 261 (87%) were with genotype 1b, 1 (0.3%) was with genotype 2a, 2 (0.7%) were with 3a and 1 (0.3%) was with genotype 4a. While the rate of SVR was 98% in patients receiving Led +Sof ± ribavirin (R), it was 100% in patients receiving PrOD ± R. Cirrhosis was found to be the only factor affecting SVR. An adverse event was observed in 60 (40.5%) of patients using PrOD or PrOD + R, and in 68 (44.7%) of those using Led + Sof or Led + Sof + R. Conclusion: In CHC patients, PrOD and Led + Sof treatments are effective and reliable treatments and shows promise.

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