Abstract:

The aim of this study was to determine the role of mean platelet volume (MPV) and ischemia modified albumin (IMA) in early diagnosis of acute mesenteric ischemia (AMI). Materials and Methods: In this study, 18 Wistar Albino rats were randomly assigned to 3 experimental groups with 6 rats in each group as; sham group without laparotomy, control group with laparotomy and mesenteric ischemia-induced group. Platelet count, MPV and IMA were studied at the end of the 120th min of superior mesenteric artery obstruction in AMI group and at the same time in other groups.   Results: In AMI group MPV and IMA values were significantly higher compared with other 2 groups, while platelet count was significantly lower . There was not any statistically significant difference between control and sham groups regarding these parameters.  Conclusion: Further clinical studies are required to define the role of these parameters in early diagnosis of AMI since AMI is a highly mortal disease if not diagnosed promptly

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