Özet:

Background: Breast cancer is the second most common malignancy related mortality in women worldwide. Multiple factors including genetics, lifestyle factors and socioeconomical etc. are associated with an increased risk of developing breast cancer. For the early detection of breast cancer a number of biochemical markers have been studied to evaluate the malignancy. Aim: To analyse serum Lactate Dehydrogenase, Gamma Glutamyl Transpeptidase, liver enzymes (SGOT, SGPT, & ALP) and total proteins in diagnosis of carcinoma breast patients and compared with controls. And evaluate the relationship of serum LDH, GGT levels with ALP of carcinoma breast patients of post-menopausal age group. Materials & Methods: The serum biochemical markers were estimated in 60(30-premenopausal women, 30-post menopausal women) clinically and histopathologically confirmed patients with carcinoma breast and 60 number of healthy age- matched individuals served as control. Lactate dehydrogenase (LDH), Serum Gamma Glutamyl Transpeptidase (GGT) and Alkaline phosphatase (ALP) were analysed and estimated. The statistical analysis was done by using SPSS software. The results were expressed as Mean±SD. The student’s paired 't'-test was carried out for comparison of data & p-value <0.005 was considered statistically significant. Results: The mean serum LDH, GGT, and ALP activities in patients with carcinoma breast were significantly (p<0.0001) increased as compared to controls, and a steady increase was observed in their levels from premenopausal to post-menopausal women. Conclusion: In this study, it is too suggests that the estimation of less specific biomarkers like LDH, GGT, and ALP can be used as routine screening tests in all suspected carcinoma breast patients because these are less expensive and easily assayed and used for diagnosing breast cancer, detecting metastasis and monitoring the cancer progression and treatment.

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