Abstract:

Preeclampsia (PE) is one of the most common gestational complications, being clinically characterized by a systolic blood pressure of 140 mmHg or higher, a diastolic blood pressure of 90 mmHg or higher, or both systolic and diastolic blood pressure above ≥140/90 mmHg,Material and Methods: In this study investigation was done to determine the contribution of different biochemical parameters of females suffering from preeclampsia and Eclampsia. The present study was carried out in the Department of Biochemistry in association of Department of General Medicine. Biochemical parameters included: Iron, Zinc, Copper, Malondialdehyde (MDA), Glutathione, Vitamin C, Vitamin E, Uric acid. The study was carried out on Case group - 100 pre-eclampsia and eclampsia patients compare to Control group - 100 normal pregnant females. Results:The mean systolic and diastolic blood pressure showed statistically significant difference (p < 0.001) between cases and controls. In case group Serum Copper level was 18.6 ± 6.2 μmol/L and in control group was 8.2 ± 2.7 μmol/L (p < 0.001). Serum iron level in case group was 18.92 ± 8.29 μmol/L and control group was 15.43 ± 5.49 μmol/L (p < 0.05). The mean serum concentrations of copper and iron showed statistically significantly difference (p < 0.05) in pre-eclampsia and eclampsia patients in comparison to the control group. The mean Serum Zinc levels showed no statistically significant difference (p = 0.07) between cases and controls. Serum Zinc level in case group was 8.3 ± 1.7 μmol/L and in control group was 9.0 ± 2.1 μmol/L. Oxidative marker between Case and control group was statistically significantly difference (p < 0.05). MDA in case group was 3.17 ±0.32 nmol/ml and Control 1.54± 0.21 nmol/ml (p < 0.001). Antioxidant marker between Case and control group was statistically significantly difference. In case group Glutathione 9.53 ± 2.46 μmol/ml and control group 11.68 ± 3.63 μmol/ml (p < 0.001). Conclusion:The results obtained support our initial hypothesis that common differences between all pregnant women and controls could be revealed, while preeclampsia and the other pregnancies would further differ indicating specific misbalance of the oxidative stress in preeclampsia.

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