Özet:

The aim of this study was to determine the diagnostic value of 18F-florodeoxyglucose Pozitron Emission Tomography / Computer Tomography (PET/BT) in the detection of pelvic and paraortic lymphatic nod metastases in early stages of cervical cancer patients. Instrument and Method: Radical histerectomy and systemic pelvic and paraaortic lymphatic nodus disection pre-PET/BT screening in the early stage of uterine cervical cancer 18 patients were included in the study. The histopathological assessment of the lymphatic nodes was considered a diagnostic standard and the PET/BT findings were compared with the histopathological findings. Results: A total of 807 (577 pelvic - 230 paraaortic) lymph nodes were sampled from 18 patients and in the histopathological examination 5 (28%) patients found 10 (1.2%) nodes (8 pelvic - 2 paraaortic) positive. General nod-based PET/BT sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were 10 % (1/10), 100 % (797/797), 100 % (1/1) 99 % (797/806) and 99 % (798/807) respectively. The general patient-based PET/BT sensitivity, specificity, PPV, NPV and accuracy were 20 % (1/5), 100 % (13/13), 100 % (1/1), 76 % (13/17), 78 % (14/18) respectively. Result: In the early stages of managing cervical cancer patients, it should be remembered that patients with micrometastatic lymphatic nodes may be as wrong negative in PET / BT. Keywords: Early stage cervical cancer; Preoperative FDG PET/BT; Pelvic and paraaortic lymphatic nod metastasis. ABSTRACT Objective: The aim of this study was to determine the diagnostic value of 18F-fluorodeoxyglucose Positron Emission Tomography / Computed Tomography (PET / CT) in detection of pelvic and paraaortic lymph nod metastases in patients with early stage uterine cervical cancer. Materials and Methods: 18 patients with early stage uterine cervical cancer who underwent PET/CT imaging before radical hysterectomy and systemic pelvic and paraaortic lymph nod disection were included in the study. Histopathological evaluation of lymph nodes was accepted as the diagnostic standard and PET/CT findings were compared with histopathological findings. Results: Of the total 807 (577 pelvic and 230 para-aortic) lymph nodes sampled from 18 patients, and 10 (1,2%) nodes (8 pelvic and 2 paraaortic) in 5 (28%) patients were positive for metastasis at histopathologic examination. The overall node-based sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT were 10% (1 of 10), 100% (797 of 797), 100% (1 of 1), 99% (797 of 806), and 99% (798 of 807), respectively. Meanwhile, the overall patient-based sensitivity, specificity, PPV, NPV, and accuracy of PET/CT were 20% (1 of 5), 100% (13 of 13), 100% (1 of 1), 76% (13 of 17), and 78% (14 of 18), respectively. Conclusions: In the management of patients with early stage uterine cervix cancer, it should be kept in mind that patients with micro-metastatic lymph nodes can be as false negative in PET / CT. Key words: Early stage uterine cervix cancer; Preoperative PET / CT; Pelvic and paraaortic lymph nodes metastasis