Özet:

In this study 40 patients, who received fentanyl or fentanyl+clonidine by patient controlled analgesia device after total abdominal histerectomy + bilateral sapingoopherectomy (TAH + BSO), were compared for analgesic efficacy, analgesic requirements, haemodynamic and adverse reactions. In Group I, PCA with fentanyl was set 0.5 µg/kg loading dose; 20 µg bolus dose and 15 min. lockout time. In Group II, PCA was set with the same drug regimen plus clonidine; 2.5 µg/kg loading dose and 10 µg bolus dose. At postoperative 0., 2., 6., 9., 12., 18. and 24. hours pain scores (Numeric Rating Scale - NRS), systolic and diastolic arterial pressures (SAP, DAP), heart rate (HR), respiratory rate (RR), SpO2, sedation, adverse reactions, total and succesful requests and patients' opinions were noted. Pain scores (after 6. hour), SAP, DAP, HR, adverse reactions and total requests were found to be lower in Group II. Although respiratory rates were found significantly lower in Group II, respiratory scores were found to be in physiologic borders in both groups. As a result, although application of fentanyl by i.v. PCA is efficient for postoperative analgesia, fentanyl+clonidine combination is found to have more efficient analgesia with lower adverse reactions and can be preferred.

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