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Background: Quality of working life results in employees' motivation of working and their demand to turn over and self-efficacy. This study aimed at determining the possible relationship between achievement motivation and the quality of working life with the moderating role of job class (therapeutic vs. non-therapeutic) among hospital staff working in some selected hospitals located in Mazandaran State, Iran. Materials and Methods: This is a correlational study with a descriptively applied research conducted in 2016. The study population included all 2,927 hospital employees working in selected hospitals located in Mazandaran state, Iran. Using Cochran's sample size formula, 341 employees were selected as randomly using stratified sampling technique by their working hospital type. The research instrument was the Persian-versions of three standard questionnaires including Herman's Achievement Motivation questionnaire, Walton's Quality of Working Life Questionnaire, and General Self-efficacy Questionnaire. Some descriptive and inferential statistics techniques were used for data analyses by applying AMOS and SPSS 19. Results: Regarding therapeutic job group, the standard regression coefficient between achievement motivation and self-efficacy was statistically significant (β= .58, t= 3.78, p= .0009). In addition, the standardized coefficient between the quality of working life and self-efficacy was statistically significant in this job class (β = .38, t= 3.77, p= .0009). Considering non-therapeutic job group, the standardized coefficient between achievement motivation and self-efficacy was not statistically significant (β = .22, t= 1.53, p= .125). Conclusion: The moderating effect of the job class was more powerful among non-therapeutic employees. Empowering hospital employees is needed, and some training opportunities need to be provided for them. 

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