Abstract:

Objective: To investigate the role of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and platelet values in predicting intrahepatic cholestasis of pregnancy (ICP) together with the fibrosis-4 (FIB-4) score. Methods: This study consisted of a patient group diagnosed with ICP (n=44) and a control group (n=53). Laboratory tests of both groups were analyzed retrospectively. Receiver operating characteristic (ROC) analysis was performed to determine cut-offs for first trimester FIB-4 score, AST, ALT and platelet values to predict the development of ICP. Results: The first trimester FIB-4 score, AST, ALT values were found to be statistically significantly higher, and the platelet value was found to be statistically significantly lower in the study group . The first trimester FIB-4 score was statistically significant in predicting the development of ICP in the third trimester (p value 0.001), and the ROC value was 0.741. When the cutoff value for the FIB-4 score is set as ≥0.425, the sensitivity is 77.3% and the specificity is 54.7%. Conclusion: First trimester FIB-4 score was found to be effective in predicting ICP. Additionally, the first trimester AST, ALT and platelet values were found to be effective in the prediction of ICP diagnosed at the third trimester.

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