Özet:

Chronic lymphocytic leukemia (CLL) is the most common subtype of leukemia. One of the most important causes of mortality and morbidity in CLL is infections. Hypogammaglobulinemia is among the conditions that increase the risk of infection. In this study, it was aimed at evaluating the patients with CLL who had hypogammaglobulinemia at the time of diagnosis, development of infections and survival data.  Material and Methods: Seventy-five patients with CLL who admitted between 2000 and 2014 at the Department of Hematology, Ankara University School of Medicine were included in this study. Patient characteristics, infections, treatment and survival data were obtained retrospectively from patient files. Categorical data were compared with Chi-square test. The value of p <0. 5 was considered significant. Overall survival (GS) was determined by the Kaplan-Meier method. Results: At the time of diagnosis, the median age of 75 patients was 59 (range: 32-85). At least 1 immunoglobulin subtype level was detected as low in 32 patients (43%). The average age of patients with low immunoglobulin levels was statistically significantly higher than those without hypogammaglobulinemia (62 to 57, p=0.03). There were 26 patients (35%) who had a moderate to severe infection in the first year after diagnosis. Patients with low levels of at least 1 immunoglobulin subtype had no significant difference in the risk of moderate to severe infections compared to patients without hypogammaglobulinemia (10 (38%) and 16 (62%), p=0.63). The 5-year overall survivals were 93% and 83% (p=0. in patients with normal and low immunoglobulin, respectively. There was no significant increase in the risk of infection in patients with low immunoglobulin levels at the time of diagnosis in CLL. Overall survival is similar to that of patients with normal immunoglobulin levels.

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