In this paper the synthesis of some substituted di – 1,2,4-triazoles and it is conversion to multi nuclear heterocyclic compounds ; described Terphthalic acid was esterified to its ethyl ester(1)by its reaction with absolute ethanol , concentrated sulfuric acid , the ethyl ester (1) was treated with hydrazine hydrate is ethanol to give the acid hydrazide (2). the hydrazide (2) then treated with ammonium thiocyanate to give thiosemicarbazide (3) , reaction of thiosemicarbazide (3) with hydrazine hydrate gave 1,4-bis( 3-thiol-4-amino-1,2,4-triazole-5-yl) benzene (4). Compound (4) treatment with three type substituted benzaldehyde gave 1,4-di hydrazones phenyl (5,6 and 7). Cyclization hydrazones compounds (5,6,7) with phosphorous oxychloride in xylene to gave bicyclic system 1,4-bis[1,2,4-triazole[3,4-b]-5-substituted – 1,3,4-thiadiazole] benzene (8,9 and 10) . On the other hand some physical parameters of compounds ( 4 -10 ) under investigation such as the Mullikan charge at the active atoms, HOMO and LUMO energy levels , hardness (η) , electronic chemical potential (µ) and global electrophilicty index (W) were theoretically calculated using ( Gaussian program ). The antibacterial activity some of the synthesis compounds was studied. The structures of the synthesized compounds were confirmed by physical and spectral methods.
Dergi Türü : Uluslararası
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