Özet:

Aim: This study aims to determine the relationship between fragility and physical function in Parkinson's disease (PD) and to investigate the physical function status according to the fragilty phenotypes. Material and methods: In this cross-sectional study, 68 patients (21 females, 47 males) diagnosed with PD were included. Fragility was assessed by the FRAGIL scale, and physical function by the short physical performance battery (SPPB) and digital hand dynamometer. According to the FRAGIL scale score, the patients were divided into three groups: non-fragil, pre-fragil, and fragil patients with PD. Results: The mean age of the patients in this study was 70.977.91 years. While 69.1% of the patients were in the pre-fragil period, 22.1% of them were fragil, and 8.8% of them were non-fragil. SPPB score and handgrip strength were 10.170.41 and 18.672.58 in the non-fragil group, 8.212.34 and 14.065.97 in the pre-fragil group, while it was 5.733.67 and 12.477.44 in the fragil group, respectively. There was a difference between the groups in terms of total SPPB score and SPPB sub-dimensions (p <0.01). SPPB scores were lower in the fragil group (p <0.01). Handgrip strength was similar between the groups (p> 0.05). A negative correlation was found between SPPB scores and the FRAGIL scale score (p <0.05). There was no relationship between handgrip strength and FRAGIL scale score (p> 0.05). Conclusion: This study showed that patients with PD were at risk for fragility. The lower extremity function, balance skills, and walking speed decrease in patients with PD according to the fragility status and severity of their fragility, while the upper extremity function does not change according to their fragilty status. Interventions/approaches related to physical function parameters such as lower extremity function, balance skills, and gait speed, which are associated with fragilty in PD may be useful in preventing, delaying, and/or reducing the effects of fragilty.

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