Özet:

Objectives: The aim of this study was to determine the ability of maternal serum plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (free ß-hCG) values ​​measured in the first trimester screening test to predict the complications that may develop in later gestational weeks, calculate the median values ​​of these parameters and compare them with those of software we use. Materials and methods: The study included 16-46 years old women who applied to biochemistry laboratory of Tokat Gaziosmanpasa University School of Medicine with gestational ages of 10 weeks and 6 days to 13 weeks and 6 days. The results of 3166 pregnant women were evaluated retrospectively. Results: The mean age of the patients was 27.43 ± 5.46 and their weight was 65.66 ± 13.13 kilograms. Crown rump lengthes (CRL) were determined as 60.71 ± 8.56 mm. Free ß-hCG levels were 55.1 ± 132.07 ng / mL and PAPP-A values ​​were 3683.53 ± 2486 mIU / l. Nuchal translucency measurements (NT) were determined as 1.38 ± 0.37mm. PAPP-A and Free ß-hCG MoM values ​​were 1.23 ± 0.68 and 1.23 ± 0.88, respectively. New median values ​​of β-hCG were found to be significantly lower than those of the program (p <0.05), while PAPP-A values ​​were significantly higher (p <0.05). Conclusion: The accuracy and performance of first trimester screening tests should be improved. Determination of median values ​​specific to the region and even to the laboratory is now inevitable

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