Abstract:

In human and veterinary medicine, after tendon injuries, adhesion and tendon breakdown are often one of the ortopedic problems. This study aimed at demonstrating the effectiveness of the repeated application of hyaluronic acid (HA) in tendon healing in a macroscopic, biomechanical and histopathological way. In the 6 months of the study, 30 spraq dosley races were used. The rates created primary tendon repair in the shell tendons were randomly divided into three groups. The rates in the first group were considered as the control group and no treatment was applied after the operation. In the second group of rates, 0.075 mL/kg HA was applied in a single dose around the tendon after the operation. The roads in the third group, after the operation 3, 7 and 14. Repeated applications were performed around the HA tendon in the same dose in the days. In the macroscopic, biomechanical and histopathological assessments carried out after euthanasia, there was a lower level of adhesion compared to the control group in the therapeutic groups carried out by HA. The macroscopic assessment found that the adhesion degree of the treatment groups was significantly low in statistical terms (P<0.05) compared to the control group. There was no statistically significant difference between the 2nd and 3rd treatment groups (P>0.05). The rate of inflammation was statistically significantly low in the 3rd group of repeated HA applications (P<0.05). There were no differences between the groups in the direction of neovascularization, fibroblastic proliferation and fibrosis (P>0.05). In the biomechanical study, the maximum resistance control in the 3rd group was prior to breakdown and more than 2 groups. As a result, it was found that HA applications for the prevention of adhesions are a available treatment option and that more detailed studies are needed when it comes to single or repeated doses of HA applications.

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