Abstract:

Purpose: Comparing clinical, biochemical and hormonal values in different polycystic over syndrome (PKOS) phenotypes. Tools and Methods: To study Dumlupınar University Evliya Çelebi Education and Research Hospital Women's Diseases and Birth Clinic from July 2015 to January 2016 with the application of PKOS diagnosed 87 patients and age - body mass index compatible, 34 healthy volunteers included a total of 121 events. The revised Rotterdam Criteria was used for the diagnosis of PKOS. Patient identifying data, biochemical and hormonal values were compared. The SPPS 21.0 program was used for statistical analysis. It was statistically considered meaningful that the value of P was less than 0.05. Results: 38 of the study group are phenotype 1 (43.67%) and 6 phenotype 2 (6%). 89), 22 were phenotype 3 (25.28) and 21 were phenotype 4 (24.13) .  The average age of PKOS and control group was respectively 23,09 ± 4,90 and 23,15 ± 6,40 (p>0.05). Although the body mass index was higher in phenotypes 1 and 2, the difference between the groups was not statistically meaningful. There was no difference between the phenotypes in the rectum ratio (p>0.05). In 63.2% of patients, insulin resistance was found. Insulin resistant phenotype 2 was observed. When Serum C reactive protein (CRP) levels were studied, there was no statistically significant difference between the groups (p>0.05). When we look at the Ferriman Gallwey scores (FGS), we found that the phenotypes had high scores of 2 and 1. The FGSs of phenotypes 1, 2 and 3 were significantly higher in comparison with the control group and phenotypes 4 (p<0.001). Luteinizan hormone (LH) was significantly higher in phenotypes 1 and 4 compared to the control group and other phenotypes (p<0.01). Although the serum testosterone levels were higher compared to the control group in the patient group (p=0.03) there was no significant difference between the phenotypes (p>0.05). The result: Our study found that there was no difference between the groups in different PKOS phenotypes, except the FGS and serum LH levels. However, in phenotype 2, insulin resistance and CRP levels were observed to be significantly high, although not statistically meaningful. This group is considered to be a relatively risky group for long-term cardiovascular morbidity, and it will be appropriate to follow closely.  Keywords: anovulation, phenotype, hyperandrogenism, polycystic over syndrome