Abstract:

Objective: Many factors, including advanced age and female gender, have been identified as negative factors for peripheric blood hematopoietic stem cell (HSC) mobilization. Similarly, blood group antigens may have an effect on the release of HSCs from the bone marrow niche into the periphery. We aimed to study the effect of ABO and Rh blood groups on peripheral blood HSC mobilization in healthy donors. Material and Method: The data of 314 healthy donors who underwent peripheric blood HSC mobilization in our center were analyzed retrospectively. Results: The number of CD34+ cells collected on the first day and in total was the least in donors with blood group A. A statistically significant relation was found between ABO blood groups and the number of CD34+ cells collected on the first day and in total. No relation was found between Rh positivity and the number of CD34+ cells collected. Conclusion: According to our research in the literature, this is the first study that investigates whether blood groups have an effect on the release of HSCs from the bone marrow niche into the periphery and we observed that blood group A is a negative risk factor for peripheric blood HSC mobilization.

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