Özet:

Objective: Objective:The antioxidant and anti-inflammatory effects of Folinic acid [(FA); Leucovorin] in a septic shock model have been investigated. Materials and Methods: FA (100 mg/kg) given thirty minutes before lipopolysaccharide (LPS; 5 mg/kg). The blood and tissue samples of control, FA, LPS and FA + LPS groups were obtained sixteen hours later of LPS intervention. Results: Sepsis resulted in a remarkable increase in alanine aminotransferase, aspartate aminotransferase, urea, creatinine, lactate, nitric oxide, Malondialdehyde (MDA), procalcitonin, tumour necrosis factor-alpha, Interleukin 1-beta levels and consumed antioxidants catalase (CAT) and glutathione (GSH) levels of the tissues. MDA, nitric oxide, GSH and CAT levels were ameliorated by FA treatment. Conclusion: FA can be used as a safe way of restoring the (anti)oxidant status of kidney and liver tissue in sepsis clinic. It can be effective in controlling inflammatory mediators, decreasing procalcitonin and regulating the metabolic process of sepsis.

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