Özet:

In this study, the electrochemical properties of epirubisin, an anthracycline drug, were studied in the Britton-Robinson tampon solution (pH 2.0-10.0) in the presence of cationic surfaces using pen graphite electrots. First of all, the parameters affecting the performance of the pen graphite electrots, for example, electrots activation, support electrolyte, pH effect, accumulation voltage and duration, surfact effect and square-wave volatility method parameters have been thoroughly studied using adsorptive scroll volatility technique. The linear range (0.01-2.0 μg mL-1) and the limit of observability (GS; 0.0018 μg mL-1) for epirubisin were later established in the best conditions of the recommended techniques achieved. The developed square wave adsorptive scratch voltametric technique has been applied with the standard adding technique to human urine.