Objective: To reveal the factors that may affect the burnout level of nurses working in a medical oncology clinic. Methods: This study was a cross-sectional observational descriptive study conducted in a medical oncology clinic. The study included 29 female nurses who were currently working in a medical oncology clinic. Participants were assessed with sociodemographic information form and Turkish versions of the occupational fatigue exhaustion/recovery scale (OFER), the professional quality of life (ProQOL) scale, and the Beck depression inventory (BDI). Participants with a low burnout score and a high burnout score were identified as group A and group B and were compared about factors that could affect burnout. Results: Group A and group B were similar in terms of sociodemographic parameters. OFER-chronic fatigue subscale median (IQR) scores for Group A and Group B were 43.0 (33.00-58.50) and 63.0 (50.0-83.0), respectively (p = 0.032). OFER-inter-shift fatigue subscale median (IQR) scores for Group A and Group B were 50.0 (37.00-57.75) and 37.0 (20.00-43.00), respectively (p = 0.005). Median scores of OFER-acute fatigue, ProQOL compassion satisfaction, and compassion fatigue, and BDI were similar between groups. In binary logistic regression analysis, the odds ratios of OFER-chronic fatigue and OFER-inter-shift fatigue were 1.027 (95% CI 0.980-1.077, p = 0.263) and 0.904 (95% CI 0.828-0.988, p = 0.025), respectively. Conclusions: Our study revealed that the most crucial factor related to the occupational burnout of nurses might be inter-shift fatigue (recovery). Interventions to target inter-shift fatigue could potentially protect nurses from burnout.
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