Özet:

Purpose: This study is designed to determine the effects of the application of CoQ10 in diabetes on some liver enzymes. In this study, 38 healthy male Wistar Albino rat were used for this purpose. The animals were divided into 5 groups. During the four-week study, the group 1 was fed with standard rat food, while the group 2 animals were given CoQ10 daily as 0.3 ml of eggs oil as intraperitoneal (IP) and 10 mg/kg of coQ10 as the same food to the group 3 animals. Diabetes experimental was created in group 4 animals with a subcutaneous (SC) injection twice a day, with a single dose of streptosotine in 0.1 M citrate buffer (pH 4.5) in a dose of 40 mg/kg. 0.1 M citrate buffer in 40 mg/kg doses in animals in Group 5 (pH 4. In this case, a experimental diabetes was created with SC injection twice a day, with a single dose of streptosotine, and then 10 mg/kg CoQ10 was administered per day as IP for four weeks. At the end of the fourth week, blood samples were taken from all animals. In these plasma samples, levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamil transpeptidase (GGT) were determined. Results: The study showed significant increases in AST, ALT, ALP and GGT levels (P<0.05) compared to the control group in the group created with diabetes. There were significant decreases (P<0.05) in the levels of these enzymes compared to the diabetes group with the application of CoQ10 to diabetic animals. Recommendation: As a result, the application of CoQ10 is believed to be beneficial against liver damage resulting from the harmful effects of diabetes.

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