Özet:

Purpose: The study of the effects of histerectomy on the levels of estradiol, progesterone and testosterone, steroidogenic hormones, in the experimental model of the female rat. In the study, a total of 45 female wheels of the Wistar Albino type were used. The rates involved in the study were randomly divided into two groups to form the study [histerectomy(n=30)] and control [sham (artificial) operation (n=15)]. In the study group, the rats were hysterectomy, and the rats in the control group were sham (artificial) operation. Blood samples were taken in the basal, postoperative 50th day and postoperative 100th day for determining hormone parameters (estradiol, progesterone, testosterone) from both groups. The results were compared between the two groups. Results: When time-related changes in hormone parameters (estradiol, progesterone, testosterone) were studied as a whole, it was found that there was no significant difference between the two groups (p>0,05). Basal and postoperative hormone parameters in the 50th and 100th days were individually treated and the levels of estradiol in the 50th day of the postoperative were significantly low compared to the control group (p=0,011), and the levels of progesterone in the 100th day of the postoperative were significantly high compared to the hysterectom group (p=0,033). The result: Considering that the levels of steroidogenic hormones after hysterectomy may be worth it, it should be remembered that hysterectomy can affect over functions. Keywords: Histerectomy, Over Functions, Steroidogenic Hormones, Rat THE EFFECT OF HYSTERECTOMY ON THE STEROIDOGENIC HORMONES ESTRADIOL, PROGESTERONE, AND TESTOSTERONE: AN EXPERIMENTAL FEMALE RAT MODEL ABSTRACT: Purpose: To investigate the effect of hysterectomy on the steroidogenic hormones estradiol, progesterone, and testosterone in an experimental female rat model. Materials and Methods: Forty-five female Wistar Albino rats were used in this study and randomly divided into two groups: the study [hysterectomy (n=30)] and the control [sham operation (n=15)] groups. Hysterectomy in the study group and sham operation in the control group were performed. In both groups, blood sampling was performed for basal, and postoperative 50th and 100th day evaluation of hormonal variables (estradiol, progesterone, testosterone). The results of the two groups were compared. Results: There was no difference in hormonal variables (estradiol, progesterone, testosterone) between the groups when the entire time interval was considered (p>0.05). When basal, and postoperative 50th and 100th day hormonal variables were evaluated separately, in the hysterectomy group, the estradiol level at postoperative day 50 was significantly lower (p=0.011), and the progesterone level at postoperative day 100 was significantly higher than the control group values (p=0.033). Conclusion: When the changes in the level of steroidogenic hormones following hysterectomy are taken into account, it should be kept in mind that hysterectomy may affect ovarian functions. Key words: Hysterectomy, Ovarian Functions, Steroidogenic Hormones, Rat