Özet:

Food protein–induced enterocolitis syndrome (FPIES) is a rare non-IgE mediated food allergy. The clinical and demographic characteristics, culprit foods and tolerance status of 17 patients with a diagnosis of FPIES who were followed up between June-2021 and December-2022 were recorded. Seventeen patients consistent with 58.8% (n=10) males diagnosed with FPIES were included in the study. The median (interquartile range) age of symptom onset was 6 months (5-7.5months) and the median age at diagnosis was 7.7 months (8–20months). Of 17 patients, 15 were diagnosed with acute FPIES and 2 were chronic FPIES. The most common culprit foods in acute FPIES were hen’s egg (n=6), cow's milk (n=4), and fish (n=3). Cow's milk (n=2) was the only culprit food in chronic FPIES. The most common clinical symptoms were vomiting (100%), pallor (77.8%), lethargy (38.9%), and diarrhea (38.9%). Eight patients (47.1%) achieved tolerance and the median age at tolerance was 23.5 months (18.3-29.5months). Tolerance was not observed in any patients with fish FPIES. There was no statistical significant difference in the characteristics and laboratory findings of patients between the groups who developed tolerance and did not tolerance (p>0.05). The prognosis of FPIES is generally acceptable and more than half of the patients acquire tolerance until 5 years. In this study, hen's egg, cow's milk, and fish were the most common culprit foods. While approximately half of the patients achieved tolerance at a median age of 23.5 months, none of the patients with fish BPIES were tolerant.

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