Abstract:

Aim: The aim of this study was to evaluate the factors affecting the duration of renal involvement in children with immunoglobulin A vasculitis (IgAV; formerly Henoch Schonlein Purpura). Methods: Data from IgAV patients who were followed up on for at least a year between January 2015 and June 2022 were analyzed retrospectively. Demographic, clinical, laboratory findings and treatments were recorded. Results: The study included 372 IgAV patients, 81 of whom had IgAV kidney involvement. Forty-six (56.8%) of the patients were male and 35 (43.2%) were female. All patients had skin involvement, 32 (39.5%) had joint involvement, 44 (54.3%) had gastrointestinal (GI) tract involvement, and 2 (2.5%) had neurologic involvement. 3 patients had hypertension at the time of diagnosis. Renal involvement was diagnosed at the time of diagnosis in 45 patients (55.5%), within the first 2 weeks in 10 patients (12.4%), between weeks 2-4 in 12 patients (14.8%), and between 1 month and 3 months in 14 patients (17.3%). After 3 months, there was no renal involvement. Renal involvement at the time of diagnosis was associated with older age and low albumin level, and renal involvement at 1-3 months was associated with joint and GI tract involvement. Among patients with renal involvement, those with renal involvement and nephrotic proteinuria at diagnosis had longer time to recovery. Patients with renal involvement and hematuria between 1-3 months had a shorter time to recovery. Conclusion: The development of IgAV-renal involvement in older age and those with low albumin levels should be carefully monitored. Especially the first 3 months is a risky period in terms of development of renal involvement.

Keywords: