Abstract:

Paliperidone is a second- generation antipsychotic which is used in the treatment of schizophrenia . It is an active metabolite of risperidone and shows almost the same high affinity for dopamine D2 receptor and serotonin 5-HT2 receptor .The data about the association between acute dystonia and paliperidone treatment is restricted in literature. In this paper, we reported two cases who devoloped acute dystonia after initiating of paliperidone treatment. We suggest that paliperidone might acts a potential dopamine D2 receptor blocking agent in some vulnerable patients and acute dystonia should kept in mind as an early side effect of paliperidone even initating with low doses.

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