Özet:

Aim Preeclampsia may cause both maternal and neonatal complications. Uteroplacental dysfunction is one of the reasons of fetal and neonatal complications in preeclampsia. Recent findings about the etiology and pathogenesis of the disease shows that inflammation is one of the factors responsible for maternal complications, thus neonatal complications should be associated with the same inflammatory process. We considered evaluating mean platelet volume (MPV) of infants born to mothers with preeclampsia, based on the findings of elevated MPV values in pregnant women with preeclampsia. Materials and methods This study was carried out at the Neonatal Intensive Care Unit of Hacettepe University Ihsan Dogramacı Children’s Hospital and consisted of 148 infants born to mothers with preeclampsia and 147 infants as a control group which were selected by stratified sampling system. Hematological parameters (mean platelet volume, hemoglobin values, white blood cell and platelet counts) and common neonatal morbidities (small for gestational age, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage and patent ductus arteriosus) were evaluated between groups. Results The infants of mothers with preeclampsia had significantly elevated MPV and hemoglobin values (p<0.0001, p:0.032) and significantly lower platelet and white blood cell counts than the control group (p:0.002, p:0.011). Small for gestational age (SGA) ratio was higher in infants of preeclamptic mothers (p<0.0001) and there was no difference between groups for other morbidities. When examining the hematological parameters, MPV and platelet counts were inversely proportional. MPV was higher in SGA infants and lower in infants with patent ductus arteriosus. Conclusion Elevated MPV values are noticed in various diseased associated with inflammation like preeclampsia. Interpreting our findings of elevated MPV values of infants born to mothers with preeclampsia, neonatal complications of preeclampsia should be related with an inflammatory process.

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