Özet:

Aim: Although monosodium glutamate is widely used in the food industry, it has effects in terms of teratogenicity, especially during pregnancy and embryogenesis. Although monosodium glutamate is widely used in the food industry, it has effects in terms of teratogenicity, especially during pregnancy and embryogenesis. Our study analyses the effect on the development of the notochord by giving monosodium glutamate to chicken egg embryos. Methods: The incubation and embryonic development follow-up of our study were held in the experimental animals laboratory of University of Health Sciences Turkey, Istanbul Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital, and the preparation and microscopy of the samples were carried out in the Pathology Department of the Cerrahpasa Faculty of Medicine. 120 fertile, pathogen-free eggs were incubated at 75% humidity and 37.4±0.2 °C until embryos reached Hamburger and Hamilton stages 9-10 (30th hour). Eggs were divided into four groups. Group 1 consisted of uninjected eggs, group 2 consisted of eggs injected with saline (10 nL 0.9 NaCl), group 3 consisted of eggs injected with 15 mg/kg monosodium glutamate (MSG); and group 4 consisted of eggs injected at regular intervals. Results: The correlation values between height, dilatation, autolysis, chest, and lumbar diameters of embryos in all groups were examined. The mean embryo length was 1.0017±0.36 cm. The mean chest diameter was 20.70±14.45 cm. The mean lumbar diameter was 10.31±14.34 cm. When the groups were compared in terms of embryo length, it was observed that the groups given MSG were significantly shorter than the control and SF groups (p=0.00). Conclusion: The amount of MSG taken with food is important because it can affect the organs. Depending on the amount consumed, MSG may adversely affect notochord development.

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