Abstract:

Objective: Diabetes Mellitus (DM) is a complex disease caused by a combination of genetic and environmental factors. Selenoprotein P (SeP) appears to play a key role in the etiopathogenesis of DM. Recently, it has been demonstrated that SeP played an important role in glucose metabolism and the regulation of insulin sensitivity as a new hepatokine. The purpose of this study was to determine whether common variations in selenoprotein P1 (SEPP1) alter the risk of Gestational Diabetes Mellitus (GDM). Materials and Methods: 72 pregnant women with GDM and 64 healthy pregnant women from the same geographic region were included in the study. Allele-specific Polymerase Chain Reaction (ASPCR) analysis was used to identify polymorphisms of the SEPP1 gene (rs3877899). Results: We found that fasting glucose, insulin, HOMA-IR, HbA1c, total cholesterol levels and weight of fetus were higher in gestational diabetic pregnants compared group to healthy pregnant women group. The frequencies of the AA, GA and GG genotypes were found as 28 %, 43 % and 29 % in pregnant women with GDM and 24 %, 50 % and 26 % in healthy pregnant women, respectively. Our results indicated that the distribution of the SePP1 genotypes and alleles did not differ significantly among subjects with or without GDM (p>0.05). Conclusions: Although SeP plays a key role in glucose metabolism and the regulation of insulin sensitivity, the SEPP1 polymorphism did not changed occurrence of GDM in our population. Different mechanisms may be involved in etiopathogenesis of GDM. However, it should be clarified with further studies in larger populations. SEPP1 (rs3877899) polymorphism has no role in development of gestational diabetes in Turkish women.

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