Abstract:

Background and Aims:Background and Aims: The aim of this study was to evaluate whether colonic mucosa is infected with Helicobacter pylori in patients with inşammatory bowel disease. Materials and Methods: The data of patients who underwent colonoscopy in the endoscopy unit were reviewed retrospectively. Of them, patients with or without inşammatory bowel disease who had at least three colon biopsy specimens including the terminal ileum, ascending colon, transverse colon, descending colon, sigmoid colon, or rectum were reviewed for the presence of gastric Helicobacter pyloriinfection. Patients with gastric Helicobacter pylori infection as evidenced by histopathologic analysis or C14urea breath test were included in the study. Patients with neoplasia or polyp and those with prior colonic resection were excluded from the study. Results: Totally, 60 patients with inşammatory bowel disease were included in this study. Sixty patients with normal colonoscopy results were included as the control group. None of the patients in either group had Helicobacter pylori infection in colonic biopsy specimens by immunohistochemical staining. Conclusions: Colonic Helicobacter pylori infection was not determined in either patients with inşammatory bowel disease or healthy controls using immunohistochemical staining. However, immunohistochemical staining might not be as sensitive as polymerase chain reaction for the detection of Helicobacter pylori in colonic mucosa. There is a need for studies to evaluate the presence of Helicobacter pylori infection in colonic

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