Abstract:

nd: Total intravenous anesthesia with propofol and a synthetic opioid is a frequently chosen anesthetic technique for posterior spinal fusion. Aims and Objectives: The aim of this study is to evaluate the effect of dexmedetomidine on propofol requirement for induction and maintenance of desired depth of anesthesia. Materials and Methods: We carried our study on 80 patients aged 20–60 years, scheduled for elective spinal surgeries under general anesthesia. The patients were divided randomly into two Groups D and P of 40 each. Patients of Group D received an initial loading dose of dexmedetomidine at 1 µg/kg over 10 min, started 15 min before induction of anesthesia followed by an infusion at a rate of 0.2 µg/kg/h. Patients of Group P received the same volume of 0.9% normal saline solution as placebo. Results: Mean induction dose of propofol was found to be significantly lesser in Group D (63.68 ± 11.368 mg) when compared with Group P (118 ± 17.042 mg). Mean maintenance dose of propofol in Group D was 148.55 ± 42.08 mg and that in Group P was 398.24 ± 64.62 mg. The total requirement of propofol and mean requirement in Group D (215.24 ± 43.652 mg) was lesser than the requirement in Group P (521.29 ± 71.098 mg). Conclusion: Administration of dexmedetomidine significantly reduces the requirement of propofol while maintaining desired depth of anesthesia without any significant complication.

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