Özet:

ABSTRACT In this study, the activities of Superoxide Dismutase (Cu,Zn-SOD), Catalase (CAT) and Glutathione Peroxidase (GSH-Px) were measured in the erythrocyte of the patients with type II Diabetes Mellitus. The research group included 50 type II diabetic patients without complications and 50 healthy volunteers. The activities of erythrocyte enzymes Cu,Zn-SOD, CAT and GSH-Px from control group were determined as 1071.7 ± 331.5 U/gHb, 175.4 ± 38.8 K/gHb, and 1381. ± 690.6 Ü/gHb respectively. In the patient with type II Diabetes Mellitus activity of the same enzymes were 653.2 ±215.5 U/gHb, 196.3 ±53.3 K/gHb, 1236 ±478.6 U/gHb . While the SOD activity of patients was significantly lower, the CAT activity was determined to be significantly higher than that of control group (p<0.05). No significant difference between the GSH-Px enzyme activity of patients and control group was observed. Considering these results, we conclude that the conditions where the glucose tolerance impaired such as Type II Diabetes Mellitus may cause in excessive production of the oxygen radicals and the oxidant/antioxidant balance in erythrocytes may be disturbed.   Key Words: Type II diabetes mellitus, erythrocyte, SOD, CAT, GSH-Px.

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