INTRODUCTION: Telmisartan is an antihypertensive drug which has been shown to have antiproliferative effects on cancer cells. It has low solubility, suboptimal oral bioavailability. To investigate potential anticancer effect of telmisartan on breast cancer cells, PLA nanoparticles were formulated with the benefit of improving its solubility. METHODS: Telmisartan loaded poly(D,L-lactide) nanoparticles were prepared by emulsion solvent evaporation method. Effect of sonication time and polymer: drug ratio on nanoparticle size and drug encapsulation was investigated. TLM loaded nanoparticles were tested against MCF-7 and MDA-MB-231 breast cancer cell lines for anti-proliferative effects. RESULTS: Nanoparticles with mean particle size 272 nm and 79 % encapsulation efficiency were obtained. Sustained release telmisartan nanoparticles (40% in 24 h) decreased cell viability down to 45% for MCF-7 cells at 72 h, even at lowest telmisartan concentration, indicating better anticancer efficiency than telmisartan solution. DISCUSSION AND CONCLUSION: It was concluded telmisartan nanoparticles could be potential anticancer agents for breast cancer, deserving further studies.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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