Özet:

This study aimed to evaluate change in glomerular filtration rate (GFR) in chronic kidney disease (CKD) patients in relation to certain 24-h ambulatory blood pressure monitoring (ABPM) parameters, anti-hypertensives and inflammatory markers. A total of 206 adult CKD patients (mean±SD age: 51.3±17.1 years, 54.9% were females) were included in this retrospective study. Data on patient demographics, comorbidity and medications, 24-h ABPM parameters (pulse rate and dipping systolic and diastolic BP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR)and GFR were recorded. The change in e-GFR values from baseline was evaluated with respect to study variables. There was a mean -1.5 mL/min/1.73m2(range -80.2 to 18.1) decline from baseline GFR during study period. The decrease in GFR from baseline was significantly lower in patients with vs. without diuretic therapy (median 1.2 vs. 0 mL/min/1.73m2, p=0.017). GFR change from baseline was positively correlated with patient age (r=0.145, p=0.040) as well as with the total (r=0.198, p=0.005), day-time (r=0.184, p=0.009) and night-time (r=0.219, p=0.003) pulse rate. No significant difference was noted in GFR change from baseline with respect to gender, antihypertensive medications other than diuretics, the dipping systolic or diastolic BP values or inflammatory markers. Our findings revealed significant correlation of age, pulse rate and diuretic usage but not dipping systolic or diastolic BP or inflammatory markers with the GFR change from baseline.

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