Özet:

We aim to compare the short-term effects of losartan therapy alone and the combination with silazapril or karvedilol on blood pressure, glycemic control, insulin resistance (IR) and lipid profile. The study was conducted in 21 patients with type 2 diabetes and hypertension. After 2 weeks of monitoring (period 1), patients received losartan 50 mg/day for 6 weeks (period 2). After 6 weeks, patients were divided into 3 groups: losartan 100 mg/day (Group 1), losartan 50 mg/day and carvedilol 25 mg/day (Group 2) or silazapril 5 mg/day (Group 3) (Period 3). After Losartan treatment, the average body mass index, blood pressure, back and back surroundings decreased significantly. The systolic blood pressure of the group in the 3rd period decreased significantly. Only in Group 3 the reduction in diastolic blood pressure was meaningful. The body mass index in Group 1 and the back circles in Group 3 and the back circles in Group 1 significantly decreased. In periods 1, 2 and 3, the levels of glucose, insulin, HOMA IR, fructosamine, HbA1c, lipid levels of the patient's hunger and emptiness have not changed significantly. High doses of losartan, losartan+silazapril and losartan+carvedilol treatments in type 2 diabetics lowered blood pressure. However, these regimes did not affect glycemic control, IR and lipid profile.