Abstract:

Purpose: The optimal fractionation schedule for radiotherapy of head and neck cancer has been controversial. The objective of this study was to test the efficacy of hyperfractionation radiotherapy on patients with head and neck cancer. Methods and Materials: Between March 1995- February 1996, 30 patients with head and neck tumors (Nasopharynx, oral cavity, larynx and maksiler sinus) were treated hyperfraction radiotherapy. 25 patients were evaluated. The mean age was 45.5. Fractions used were 1.2 Gy twice-a-day with a curative intent on all patients, to a total mean dose 6074.4 Gy. Results: With a follow-up of min 2 months-9 months. 18 patients had cervical lymphadenopaty (N+). The number of of patients at each clinical stage were as follows: stage IV ,18; stage III, 4; stage II, 2; Stage I, 1. Loca-regional complete response was observed in % 56 (14 patients). Local complet response rate was % 56, regional complete response rate was % 83. Regional response rate was higher than local response rate. %40 (10 patients) had parsiyal response. No relations was observed between dose and local control rate. No patients had grade 4 toxicity. % 28 patients had require treatment interuptions due to acute reactions. Severe late toxicity was not observed ( %36 grade 1 larynx eudema, % 24 grade 3 xerostomia, % 8 grade 1 disphaji). Conclusion: Our data indicates that hyperfractionation radiotherapy for head and neck cancer is both feasible and effective, with acceptable toxicities. Key Words: Hyperfractionation, radiotherapy, head-neck cancer

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