Özet:

There is different results in studies made with type 2 diabetic patients to evaluate relationship between neuropathy with fasting plasma homocysteine levels, and also there is not enough knowledge on this subject. The purpose of this study is to evaluate relationship between chronic diabetic complications neuropathy, ischemic hearth disease and hypertension with fasting plasma homocysteine levels on type 2 diabetic patients. We evaluated 73 type 2 diabetic patients ( 53 women, 20 men mean age 56.9±9.2 ) whose diagnosis established according to ADA criteria at Haydarpafla Numune Hospital Diabetes Mellitus Outpatientclinic. Plasma fasting homocysteine levels are determined. Patients are grouped according to presence and absence of ischemic hearth disease and neuropathy and then they compared with each other. As a result patients having ischemic hearth disease, neuropathy have high fasting plasma homocysteine levels (In order; 15.4±3.5 μmol/L to 11.3±2.7 μmol/L, p=0.001; 13.4±3.5 μmol/L to 11±2.7 μmol/L, p=0.00001). In addition patients who have arterial hypertension have higher fasting plasma homocysteine levels then patients who do not have arterial hypertension (14.3±3.1 μmol/L to 10.1±2.1 μmol/L, p=0.0001) High plasma homocysteine level may be an important risk factor for ischemic hearth disease and diabetic neuropathy in type 2 diabetes mellitus. New researches are needed to prove the effects of lowering high plasma homocysteine levels with treatment on diabetic complications.

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