Özet:

Aim: Oxidized LDL, which stimulates signaling pathways that activate inflammatory reactions in endothelial cells during atherosclerosis, is defined as an important pathogenic factor in the development of cardiovascular diseases. The oxidized LDL receptor (LOX-1), which is the main receptor for oxidized LDL in endothelial cells, has the ability to specifically bind, internalize and degrade oxidized LDLs in endothelial cells. In this study, it was aimed to investigate the effect of 3'UTR188C>T polymorphism in the OLR1 gene encoding LOX-1 on serum oxidized LDL and lipid levels in the study groups consisting of coronary artery disease (CAD) patients and healthy controls, and to determine its relationship with lipid parameters in patients with CAD. Methods: Polymerase Chain Reaction and Restriction Fragment Length Polymorphism methods were used to detect the OLR1 gene 3'UTR188C>T polymorphism in groups of 50 CAD patients and 34 healthy controls. Statistical analyzes were performed with SPSS 20.0. Results: In the CAD group, oxidized LDL (p<0.001), total-cholesterol (p=0.020), Body Mass Indeks (BMI) (p=0.015), systolic (p<0.001) and diastolic (p=0.002) blood pressure levels and smoking frequency p=0.002) were higher, and serum HDL-C levels (p<0.001) were lower compared to healthy controls. OLR1 3'UTR188C>T genotype and allele distributions were found to be similar between the groups (p>0.05). The 188T allele was associated with higher oxidized LDL levels in both CAD (p<0.001) and control (p=0.013) groups. Patients with the 188TT genotype had high oxidized LDL (p<0.001), total cholesterol, LDL-cholesterol, triglyceride, and VLDL-cholesterol levels. Similarly, in healthy controls, the 188TT genotype was associated with high oxidized LDL, total- and LDL-cholesterol, triglyceride, VLDL-cholesterol, systolic blood pressure, and low serum HDL-cholesterol. Conclusion: Our findings indicate that the OLR1 3'UTR188C>T polymorphism may be associated with the development of CAD with its effects in favor of both serum oxidized LDL, which is a proatherogenic molecule, and an atherogenic lipid profile.

Anahtar Kelimeler: