Abstract:

Objective: Acute respiratory distress syndrome (ARDS) is a clinical syndrome that can develop due to pulmonary or extrapulmonary causes, causing serious loss of function or mortality in the lungs. Dexpanthenol is an important therapeutic agent with antioxidant and anti-inflammatory effects. In the study, anti-inflammatory and antioxidant properties of dexpanthenol were evaluated in the acute respiratory distress model created using oleic acid. Material and Method: For this purpose, 50 female Wistar-albino rats were divided into five groups (n:10). The groups were named as Control (C), Oleic acid (O), Dexpanthenol+Oleic acid (DO), Dexpanthenol+Oleic acid+Despanthenol (DOD) and Oleic acid+Dexpanthenol (OD). After the rats were sacrificed, levels of interleukin-1α and Tumor Necrosis Factor-alpha in serum samples were determined. In the lung tissue, histopathological examination and measurements of malondialdehyde tissue, glutathione peroxidase, catalase enzyme activity levels were made with light microscopy. Results: The results obtained showed that histopathologically significant acute lung injury was detected in the group that was not treated with oleic acid. Biochemical analyzes performed on tissue samples support histopathological results. Results from treatment groups show that the damage caused by oleic acid decreases with dexpanthenol treatment. Especially MDA levels as oxidative parameter and CAT and GSH levels as antioxidant parameters show the effect of oxidative damage. Conclusions: In conclusion, it is thought that the application of dexpanthenol is effective in preventing the development of experimental acute respiratory distress syndrome, and this effect is due to the anti-inflammatory and antioxidant properties of dexpanthenol.

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