Abstract:

Abstract The aim of the study is to investigate the effects of exercise on the cardiovascular system and especially to understand the relationship between endothelial progenitor cells (EPC) and exercise. Health sciences publications between 2003 and 2023 were searched and 8 different databases were used, examining the results of the studies in the current literature, how exercise activates EPCs, its effects on these cells and their potential mechanisms are summarized. Differences were observed in terms of exercise protocol, intensity and duration. Besides the studies showing that exercise has positive effects on vascular health, the relationship between different exercise intensities and durations is still unclear. VEGF, a key marker of angiogenesis, and CD34, a surface marker of endothelial cells, play a critical role in regulating blood vessel growth. The therapeutic potential of exercise in mobilizing EPH into the peripheral blood in persons with cardiovascular disease is not yet clear. Therefore, this study aims to evaluate the effects of single and repetitive exercise on circulating levels of EPHs in adults with cardiovascular risk factors and healthy individuals. In conclusion, it is important to investigate the relationship between physical activity and angiogenesis in more detail to better understand the effects of exercise on vascular health. These studies will help us better understand the potential of exercise and physical activity in the treatment and prevention of cardiovascular diseases.

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