Özet:

Summary: This study compared the effectiveness of tropisetrone and metoclopramide in preventing postoperative nausea-vomiting (PONV) of the patients (n=40) who underwent thyroidectomy under general anesthesia. In our randomized double-blind study, 40 patients (between the ages 18-70 years) who were classified in the American Society of Anesthesiologists (ASA) I and II groups were classified into two groups, with 20 patients in each. Before induction, 10 mg metoclopramide was administered to metoclopramide group (Group M), while 2 mg tropisetrone was administered to tropisetrone group (Group T) intravenously. All patients had standard general anesthesia. Antiemetic and side effects of the drugs, and the antiemetic requirements of the patients in both groups were followed up for 24 hours. When postoperative nausea-vomiting scores of the groups were compared, the number of patients with a score of 0 was statistically significantly higher in Group M than in Group T (p=0.027), and no differences were detected among the other scores. The frequency of nausea-vomiting was almost the same in both groups. There were no statistically significant differences between the groups for side effects. The results of this study indicated that 2 mg intravenous tropisetron application before induction of general anesthesia in thyroidectomy patients prevents postoperative nausea-vomiting better than metoclopramide in 24-hour period. In conclusion, tropisetrone may be used as a long-lasting antiemetic drug to prevent postoperative nausea-vomiting

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