Abstract:

Diabetes mellitus is a chronic disease characterized by decreased insulin synthesis or increased blood glucose due to insulin resistance. In this study, we aimed to investigate the protective role of Origanum majorana L. on the biochemical parameters of rats induced by streptozotocin (STZ). Male Sprague-Dawley (SD) rats weighing 300-400 g were used. Rats were divided into 3 groups control, diabetes mellitus, and diabetes mellitus + Origanum majorana L. Citrate buffer was used i.p. in the control group. To induce experimental diabetes in rats, streptozotocin (60 mg/kg) was injected intraperitoneally (i.p.). After 48 hours, rats with blood glucose values higher than 200 mg/dL were considered diabetic. Diabetic rats were divided into two groups. While the first group was not treated, the second group received 200 mg/kg of Origanum majorana L. extract for 6 weeks. In this study, Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), and creatinine values were measured in serum. Malondialdehyde (MDA) and glutathione (GSH) levels were measured in kidney and liver tissues. It was found that AST, ALT, and creatinine values increased in diabetes and decreased significantly in the treatment group. MDA levels were increased and GSH values were decreased in diabetes. Origanum majorana L. treatment decreased lipid peroxidation and resulted in a significant increase in GSH levels. In conclusion, our findings show that Origanum majorana L. treatment has a protective effect against nephropathy in diabetes by preventing oxidative damage.

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