Abstract:

Surface antigen and antibodies for hepatitis B are occasionally met with patients with negative, only total anti-HBc positive. In our clinic between November 2000 and June 2004, 39 (5.8%) of the 767 patients studied with hepatitis indicators found isolated anti-HBc positive. 14 of the patients with isolated anti-HBc positive were female and 25 male, with an average age of 49.8±10.33. These patients were given a recombinant hepatitis B virus vaccine in the months 0, 1 and 6. One month after each vaccination, anti-HBs thyroid was checked. The symptoms of hepatitis were studied with the ELISA test of the 3rd generation. In 1 of the cases (2.6%) HBeAg, in 10 (25,6%) anti-HBe and in 3 (7.7%) anti-HCV positivity were identified. 20 (51.2%) patients after the first vaccination, 31 patients (86.1%) and 3 patients after the second vaccination. After vaccination, an anti-HBs level ≥10 IU/L was detected in 32 patients (91.4 percent). 4 people did not take part in the 2nd and 3rd vaccines, 1 person did not take part in the 3rd vaccines. Two (5.1%) cases did not provide adequate immunity after 3 doses of vaccination. As a result, high levels of protective antibodies are provided with vaccination in people with isolated anti-HBc positive. Instead of conducting direct nucleic acid tests in these patients, considerable savings can be provided by the treatment of patients who do not respond to the vaccine only.

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