Abstract:

Introduction and purpose: Skin cancer is one of the most common cancers. These cancers are usually studied in two groups as non-melanoma and melanoma, and most of them are non-melanoma. The incidence and mortality rate of skin cancers is increasing worldwide. In this study, we wanted to study the values of malondialdehit (MDA), which is an oxidative stress indicator with molecules such as cellular antioxidants such as superoxidant dismutase (SOD), catalase (CAT), reduced glutation (GSH), glutation reduction (GR), glutation peroxidase (GPx) and skin cancer patients. Materials and methods: Prospective study was implemented in accordance with the World Helsinki Declaration modified. This study was conducted at the Department of Dermatology of the University Hospital. The study included 30 skin cancer patients and 30 healthy volunteers. The study evaluated cellular antioxidants and malondialdehitis levels in the serums of participants Results: The study was conducted with a total of 60 people, including 33 men (55%) and 27 women (45). There were no significant differences between the age and gender variables compared according to the patient and control group of the participants (p>0.05). The difference between GPx, GR, GSH, SOD, MDA, CAT values, patient and control group average has been statistically significant (p<0.05). Result: This study has shown that antioxidant serum levels are reduced in skin cancer patients and that the MDA, which is an oxidative stress indicator, is high. Keyword ̈kler: skin cancer; superoxide dismutaz; catalase ABSTRACT Introduction and objectives: Skin cancers are one of the most common cancers. These cancers are usually examined under two groups as non-melanomas and melanomas, and most non-melanomas are. The incidence and mortality rates of skin cancers are increasing all over the world. In this study, we want to investigated the intracellular antioxidants such as superoxide dismutase (SOD), catalase (CAT), reductase glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx) and malondialdehyde (MDA) values, which are oxidative stress markers, in skin cancer patients Material and method: The prospective study was carried out according to the modified World Helsinki Declaration. This study was done in the dermatology department of the university hospital. Thirty skin cancer patients and 30 healthy volunteers were included in the study. Intracellular antioxidants and levels of malondialdehyde were evaluated by participants in the study Results: The study consisted of 33 men (55%) and 27 women (45%). There was no significant difference between the age and gender variables of the study participants according to the patient and control group (p>0.05). The difference between GPx, GR, GSH, SOD, MDA, CAT values, patient and control group average were statistically significant (p<0.05). Conclusion: This study has shown that antioxidant serum levels are decreased in skin cancer patients and MDA, an oxidative stress marker, is high. Keywords: Skin cancer; Superoxide dismutase; Catalase This study was supported by the University of Yunnan's Scientific Research Headquarters, with the project number 2015-TF-B321.

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