Abstract:

Purpose: To evaluate the effectiveness of sß-HCG and PAPP-A MoM values in the range of 0.5-2.5 MoM in maternal serum in predicting fetal sex, newborn weight and height. Material and methods: The sß-HCG and PAPP-A values of the screening test biochemical components of 519 single, uncomplicated pregnancies that were screened for anomaly for the first trimester screening were retrospectively compared with the sex, height and weight data of the postpartum newborn. Results: It was found that sß-HCG MoM value was associated with newborn gender (U: 29240.5, p: 0.01) and was higher in fetuses of female gender. In the ROC analysis, it was found that the sß-HCG MoM value was statistically significant (AUC: 56.6%, confidence interval: 0.516-0.615, p: 0.01) in identifying the female gender. The sensitivity of sß-HCG MoM value in predicting the newborn gender was 66.3% and the specificity was 51.9% (cut off value: 0.855 MoM). PAPP-A MoM value was positively correlated with newborn weight (r: 0.175, p: <0.001) and height (r: 0.166, p: <0.001) and there was a very weak correlation between sß-HCG MoM value and newborn height. (r: 0.099, p: <0.005) were monitored. Conclusion: Our study showed that sß-HCG MoM value, which is one of the first trimester screening test biochemical markers, is associated with fetal gender. This relationship is not sufficient to be used clinically, as there are methods that can predict fetal sex with 100% accuracy today, but it can still give an idea for fetal sex in the evaluation of some genetic inherited diseases. In addition, in our study, it was observed that the PAPP-A MoM level in uncomplicated pregnant women gave information about parameters showing fetal development such as the height and weight of the newborn. We believe that this relationship will be further clarified by conducting comprehensive prospective studies in which many socio-demographic factors affecting fetal development are taken into account.

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